#Biotech
88
2026-10-28
jlcjak/neurband
S
Open, minimal sEMG wristband like the Meta Neural Band: 8-ch ADS1298 + nRF52832 BLE, dry gold electrodes on a flex, 3D-printed band. KiCad, FreeCAD, Zephyr, Python, simulations.
2026-09-10
aycibatuhan/nervous-system-atlas
A
A browser-based 3D atlas of clinical neuroanatomy in MNI152 space: 592 meshes with synchronised MRI slices, arterial territories, traced pathways, a syndrome and lesion mode, clinical topics, a glossary and a quiz. Every entry cites open-access sources. English and Turkish.
2026-09-15
suanmiao/fly-self-driving
A
A fruit fly connectome (165k neurons, 25.6M synapses) trained to drive a simulated street from pixels. Code, patches, renderer, results.
2026-08-23
yacine-baghli/DYB-Pro
B
DYB Pro hands the protein design pipeline to Devin: state a goal, add sequences, and an autonomous in-silico cycle returns a ranked, order-ready wet-lab shortlist at a fraction of the cost. Devin orchestrates specialist agents whose results commit to a version graph the next cycle reads.
2026-10-07
daveyburke/picofold
A
A *minimal* protein structure predictor written in ~200 lines of *readable* PyTorch.
2026-09-13
nftechie/flm
A
Train and chat with a frozen language model coupled to the full retained MaleCNS fly connectome.
2026-09-06
ashemag/human-atlas
B
Open-source 3D anatomy explorer: 2,234 selectable BodyParts3D meshes, system layers, search, and exploded views.
2026-09-07
averysader/dock-postprocess
B
Open-source SBDD toolkit for standardized docking-pose import, restrained OpenMM minimization, pose QC, protein-ligand interaction analysis, ligand strain analysis, and integrated design prioritization. Supports single receptors, but also multichain receptors, molecular glues, and PROTAC ternary complexes.
2026-09-16
sokrypton/protein_fighter
B
Street Fighter-style game with two humanoid proteins drawn live by py2Dmol; hits unfold them in AlphaFold pLDDT colours
2026-09-10
Trinkle23897/URBER
B
Code for URBER: Ultrafast Rule-Based Escape Routing Method for Large-Scale Sample Delivery Biochips
2026-09-10
JkingYu/DiffExplorer
B
Differential analysis tool for coding-free researchers – instant statistical results and charts, ready for your lab meeting. Just unzip and run! No-coding!
2026-09-15
ashemag/fly-brain-atlas
B
Interactive MaleCNS fly brain atlas with native regional and neuron reconstructions
2026-09-12
flybook-git/Main
C
A full retained fly-connectome simulation with experimental memory and guarded Coinbase AgentKit trading actions.
2026-09-18
bennjordan/fruitflysynth
B
An interactive resynthesis of a male fruit fly's mating sounds utilizing the recently mapped neural dataset.
2026-09-13
marketcalls/openfly
B
A fruit fly connectome (MaleCNS v1.0) trading an intraday NIFTY straddle through OpenAlgo.
2026-09-03
ZekunCheng/novoweave
C
NovoWeave — a conceptual generative protein-design framework (non-functional pseudocode).
2026-09-14
Decentricity/mindmeld-with-fly
B
Real-time Muse EEG driving one Drosophila MaleCNS reservoir (mind meld)
2026-09-11
nftechie/stonkfly
C
A full retained fly-connectome simulation with experimental memory and guarded Coinbase AgentKit trading actions.
2026-09-16
FLModel/flm
C
Train and chat with a frozen language model coupled to the full retained MaleCNS fly connectome.
2026-08-23
Forsy-AI/biosecurity-agent
C
AI agent that builds a live biosecurity world around any target.
2026-09-14
PtPavloTkachenko/fly-brain-spectacles
C
Hologram fruit flies on Snap Spectacles (2024), each driven by the full MaleCNS fly connectome running on a Mac (bit-exact Metal GPU kernel)
2026-10-26
BioNanomics/openflexure-light-sheet
C
Student-led BioNanomics light-sheet microscopy project based on SPIM-DoMB and OpenFlexure sample positioning.
2026-09-28
Gaoyuan-0423/biomedical-paper-reader
C
Single biomedical paper close-reading skill: understand research logic figure by figure, assess evidence boundaries, and distill testable study designs.
2026-09-17
SpikeCalls/FlyDrones
C
A fruit fly connectome as a drone pilot. Camera -> fly eyes -> spiking brain -> descending neurons -> drone. Live 3D demo in your browser.
2026-09-13
cobanov/awesome-fly
D
A curated list of fruit fly connectome projects: MaleCNS, FlyWire, brain simulations, embodied models, games, and research tools.
2026-10-14
yulin-zhang2026/Trifuse-DTI-pd1-prioritization
C
Public code release for TriFuse-DTI: multitask small-molecule and protein representation learning for PD-1 association prioritization.
2026-09-11
MarkUnthank/flyhard
D
A connectome-based fruit fly physically learning to operate a steering wheel in CARLA
2026-10-19
Dong-Fang-Bu-Bai/btr-dualrag
D
Source code for BTR-dualRAG: Bioinformatics Tool Recommendation With Dual Retrieval-Augmented Generation
2026-08-25
daddydrac/oncology_sequencing_workbench
C
GPU-ready workbench for oncology DNA sequencing that combines JupyterLab, Python/Biopython, R/Bioconductor, real DNA datasets, genomics tools, and seamless R↔Python notebooks
2026-09-12
fruitflydev/flycoinrh
D
A real fruit fly connectome, 165,122 neurons, launching tokens on Robinhood Chain
2026-10-23
talharaziq/Advanced-Bioinformatics
C
A free, hands-on bioinformatics roadmap from Linux, Python & R to RNA-seq, genomics, Bioconductor, and advanced transcriptomics. Curated English tutorials, YouTube playlists, practical exercises, and research tools.
2026-09-16
shailendraaher1/END-TO-END-Clinical-SAS-Project-Oncology-Raw-Data-CDISC-SDTM-ADaM-TLF-QC-Statistical-Programming
C
This project showcases an end-to-end clinical Trial data transformation workflow for a Phase III Oncology (Lung Cancer) clinical trial (ONCO-PEMBRO-500) using SAS OnDemand. It demonstrates complete CDISC implementation from simulated raw data to SDTM mapping, ADaM analysis-ready datasets, and regulatory-compliant TLFs with QC validation.
2026-09-10
dj-thank/fly-effect
D
Resource-aware open research on neural circuits, bodies, and simulated organisms. Starting with Drosophila.
2026-09-29
jonasherminiodev/resnet152v2-skin-cancer-ham10000
D
🔬 Aplicação Web (Flask + SQLAlchemy) integrada a Deep Learning (ResNet152V2 / Keras) para auxílio ao diagnóstico de câncer de pele (Dataset HAM10000), com 99,01% de acurácia e inferência em 1,17s.
2026-11-05
LPDI-EPFL/lddm
unrated
A Unified 3D Generative Model for Synthesizable Structure-Based Drug Design.
2026-11-03
FreedomIntelligence/BodyVista
unrated
BodyVista, learn human anatomy through immersive exploration. 🫁 🦷 🫀
2026-10-31
xxPcy/PharmaLLM-Agent
unrated
Medical LLM agent and MRI segmentation workspace built on PharmaLLM, with LangGraph, vLLM, and BEU-Net.
2026-10-24
kidous2333/SABER
unrated
SABER enables identity-resolved quantification of multi-animal social behavior
2026-10-22
RosettaCommons/chaperone
unrated
A unified framework for making structural biology tools interoperable.
2026-10-21
Henryfud/nema
unrated
A 302 neuron network on the real C. elegans wiring diagram, with a steering layer for local language models.
2026-10-21
styczynski/bioseqdb
unrated
Genomic sequence storage, indexing and alignment inside PostgreSQL: https://bioseqdb.com/
2026-10-16
DenisSergeevitch/desktop-fly
unrated
A 3D fruit fly living on your macOS desktop, driven by a live spiking simulation of the real FlyWire connectome
2026-10-16
GENTEL-lab/Fold2Reason
unrated
Official code for Fold2Reason: Enhancing general reasoning in language models through protein-structure post-training.
2026-10-16
Garinmckayl/anima
unrated
Anima: a Claude Code skill that turns a biology idea into an interactive, sourced, isometric figure. Dopamine receptors, stimulants, addiction circuits, semaglutide.
2026-10-16
NingyuSUN/bioai-evidence-validator
unrated
Evidence validation and policy engine for AI-assisted biological curation
2026-10-16
PacesaLab/BindCraft2
unrated
Easy to use suite for designing a wide range of protein binder modalities.
2026-10-16
QING1105/ezST
unrated
10x Visium spatial transcriptomics analysis skills for Codex — staged workflow with human review gates and LLM biological interpretation.
2026-10-16
aurekaresearch/OpenDDE-Harness
unrated
A Harness System for Open-source Drug Discovery Engine
2026-10-16
flybook-git/flybook
unrated
A full retained fly-connectome simulation with experimental memory and guarded Coinbase AgentKit trading actions.
2026-10-16
heise3/ExtremaRank
unrated
Native R and Python sample-deletion robustness for omics: candidate certificates, minimum deletion bounds, Bioconductor model refits and donor-level pseudobulk
2026-10-16
judegomila/OnCo
unrated
OnCo: total information dominance on cancer. A public, cited knowledge graph of oncology with a website, JSON API, MCP server and CLI: one page per cancer, treatment, target, trial, institution, person and idea.
2026-10-16
nftechie/doomfly
unrated
Fly-connectome simulation controlling a live Doom arena, with experimental neural plasticity, spectator UI, and scientific validation reports.
2026-10-16
ruoyuw22-byte/NeuroMorph-Assessment
unrated
An automated structural MRI morphometry system integrating CAT12 processing, brain tissue quantification, visualization, and automated report generation.
2026-10-16
tubban1/fly-eye
unrated
FlyEye is a browser experiment and developer kit built around a real, signed Drosophila MaleCNS-derived connectome subgraph.
2026-10-16
wilbert-MD-PhD/medical-illustration
unrated
A medical drawing Skill for AI agents such as Codex and Claude Code, producing evidence-backed medical illustrations, popular-science comics and research figures, with editable output and review records.
2026-10-11
Show HN: tgv: Genome viewer for you and your agents
unrated
Hi HN, I’m sharing tgv, a new kind of genome viewer built for humans-agent collaboration in genomics. I work in a cancer diagnostics lab and we check cancer patients’ sequencing data in genome viewers every day. Frustrated by the standard tools, last year I built tgv, a Vim-style, keyboard-driven genome viewer. In 2026, while agents are scarily good at bioinformatics, bioinformatics tools haven’t kept up. tgv now brings a new kind of research workflow: expose multi-omics data to agents through a fast SQL data layer and they explain the analysis right in the viewer. The TUI is just the start.
2026-10-11
Show HN: Dewey: a connectome-driven fruit fly for your macOS menu bar
unrated
I have connected the a reduced circuit from the Janelia FlyEM male CNS connectome (v1.0) to a 3D model of a fruit fly and now have a fruit fly living in my macOS menu bar. Next to continuing the long lineage of desktop creatures (the 90s Dancing Baby!) it raises a few questions: with Dewey driven by a 'real' connectome is it OK to bring this thing alive in a virtual environment? Is it purely reflexive? What about a bee, a social animal? To be on the safe side: Dewey can get some company on your desktop by adding a few friends. see also: https://0110.be/posts/Dewey%3A_a_connectome-driven_fruit_fly...
2026-10-08
Show HN: Checkout this open-source, local-first bioinformatics/AI desktop app
unrated
So the basic idea behind Liatir is to have a desktop environment that works like a virtual lab for bioinformatics to do your work locally, without having to send data to a cloud service or glue together a bunch of separate tools and interfaces. You shouldn’t need to write a single line of code to use it, but if you do know how to code, it's as extensible as you want it to be with the plugin system supporting Node, Python and Rust. It provides regular bioinformatics tools, local scientific AI models, integrations with workflow systems such as Nextflow, API calls when you need to connect to external data or environments, scientific viewers, and visual pipelines that tie all of those pieces together. Oh and the AI models are self-contained boxes so you do not need to set up anything and just run them. Hope you'll find this interesting.
2026-10-07
Show HN: Bio ML Tools in the Browser
unrated
This was borne from frustration installing various biology ML tools (protein structure prediction, sequence prediction, backbone generation etc) and setting up workflows for them. I set up a CLI tool and Rust + Python lib to make it "just work", then built on top of it. This site is a web UI, with each tool's page based on its individual capabilities and docs. There is some functionality for linking outputs to inputs, and managing past jobs. I also integrated it into my GUI PC software to run locally and manipulate the outputs. I've been using the site when on my tablet, or generally when away from a suitably powerful PC.
2026-10-04
Show HN: Linnaeus, a daily biological taxonomy game
unrated
What this is: Each day there's one target species, and you classify it level by level (from more general to more specific categories), with 10 seconds per choice. Faster answers score more, and there are daily and monthly leaderboards. Why: I wanted to try out agentic coding (a bit late to the party I know). A friend gifted me a week of Claude, and this is what I got in 3 afternoons of full vibe-coding. I've had the idea for this game for a while (I'm a philosopher of biology), and this was a good toy project for it. I'd never vibe-code like this in a serious project, but wanted to see how far I could get / how good frontier models were, and I'm honestly impressed. I have mixed feelings about the whole experience, but I could have never done this so fast without it. Stack: It's made with Svelte 5 and CF workers & D1. I've worked with both in the past and knew it's good for a little (free to host) side project like this. Feedback welcome, especially on whether the 10 seconds feels right (I wanted to avoid people googling the categories while playing).
2026-09-22
Show HN: flyOS – A fruit fly connectome simulated in real time on an iPhone
unrated
Hey HN, I'm Cory. When I saw Google release the fruit fly connectome, I wanted to experiment with it myself and better understand how the fruit fly brain works, so I started hacking on a few different iOS projects. Originally I was going to create an app that let you experience BEING a fruit fly with VR, but then I realized that a fruit fly's main sense is its smell, and an iPhone can't smell. So I ended up building an app based on all of the senses an iPhone has that we could wire to a fruit fly. I came up with flyOS: basically the camera is its eyes, the CPU is its brain, etc. The neuron simulator is written from scratch in Swift and runs in real time on the phone's CPU, with no server involved. Yes, this is partly a joke. But it's also a serious app that lets you view the neurons of a simulated fly in real time, which I think is pretty cool. I wrote a white paper and put it online to share the process of building this, and why I ultimately only ended up using 4,895 neurons out of the total 166,000 in the release. Would love your feedback and thoughts as to how I could make the fly even more realistic and alive.
2026-09-21
Show HN: Vsqrd – AWS for Biology Experiments
unrated
Hi hn. We built VSQRD, which is a place to order and run outsourced preclinical studies. Right now biotechs that outsource studies to CROs (contract research organizations) have to find them manually. That makes it hard to find the right expertise at the right price. But hey it doesn't have to be this way!! We built vsqrd.com, where CROs can list their study offerings and biotechs can compare and order from them directly. We handle the billing and legal work in the background. We’re starting with low-stakes non-GLP work like cell viability assays and basic in vitro testing. Over time we want to support the entire outsourcing chain all the way to clinical work. If you’re a CRO looking to run more studies or a biotech looking to outsource one sign up!
2026-09-10
Alpha-Park/genpark-izhikevich-spiking-neuron-bursting-skill
unrated
Izhikevich phenomenological spiking neuron model reproducing tonic spiking, phasic spiking, and chattering bursting patterns via two coupled 2D ODEs.
2026-09-10
Alpha-Park/genpark-rank-order-temporal-spike-encoder-skill
unrated
Rank Order Temporal Spike Encoder converting continuous multi-dimensional sensory features into exact millisecond spike arrival sequences.
2026-09-10
alphaparkinc/genpark-izhikevich-spiking-neuron-bursting-skill
unrated
Izhikevich phenomenological spiking neuron model reproducing tonic spiking, phasic spiking, and chattering bursting patterns via two coupled 2D ODEs.
2026-09-10
Show HN: TabBench-Bio: A benchmark for ML methods on tabular biomedical datasets
unrated
A benchmark for ml methods on tabular biomedical datasets. Select your modality / feature size so you can use this to shortlist a few ml methods.
2026-09-06
Show HN: Genetic Distance Map
unrated
I created an interactive map of genetic similarity between populations, based on the Moriopoulos Collection 2025 ( https://genarchivist.net/showthread.php?tid=1449). Each data point is a 25-dimensional representation (Global25), and I use Euclidean distance. There is already https://genetic-distance.com/, where you can look at the closest populations as a table. The vis should come with many caveats. One is that it is based on the data (and their quality) that is there, which does not cover all populations. Second, the localization of groups is done via LLMs (Claude), and one of the limitations is that a whole population (sometimes as dispersed as "Ashkenazi Jews") is put in one location, sometimes arbitrarily. Third, the interpolation of colours is purely decorative. Source: https://github.com/stared/genetic-distance-map With all that in mind, enjoy! See which populations are most related to Vikings, Mycenaean Greeks, or Canaanites. How about the modern diasporas of Ashkenazim or Roma?
2026-08-29
OpenELIS Global
unrated
Laboratory information system (LIS/LIMS) for clinical, public health, environmental and vector surveillance labs. FHIR-native, with analyzer integration (ASTM/HL7), quality control and national-scale reporting. (Demo, Source Code) MPL-2.0 Java/Docker
2026-08-27
alphaparkinc/genpark-biochemical-protein-ligand-binding-affinity-predictor-skill
unrated
Biochemical protein-ligand binding affinity predictor for drug discovery (Chai Discovery style)